Fine-tuning of ferrocene redox potentials towards multiplex DNA detection
نویسندگان
چکیده
منابع مشابه
Design and fine-tuning redox potentials of metalloproteins involved in electron transfer in bioenergetics.
Redox potentials are a major contributor in controlling the electron transfer (ET) rates and thus regulating the ET processes in the bioenergetics. To maximize the efficiency of the ET process, one needs to master the art of tuning the redox potential, especially in metalloproteins, as they represent major classes of ET proteins. In this review, we first describe the importance of tuning the re...
متن کاملFerrocene conjugates of dUTP for enzymatic redox labelling of DNA.
Two ferrocene-labelled analogues of dTTP, 5-(3-ferrocenecarboxamidopropenyl-1) 2'-deoxyuridine 5'-triphosphate (Fc1-dUTP) and 5-(3-ferroceneacet-amidopropenyl-1) 2'-deoxyuridine 5'-triphosphate (Fc2-dUTP) have been produced to demonstrate the incorporation of redox labels into DNA by polymerases. Cyclic voltammetry indicates that the ferrocenyl moieties display reversible redox behaviour in aqu...
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We explore regions of parameter space in a simple exponential model of the form V = V0 e −λ Q Mp that are allowed by observational constraints. We find that the level of fine tuning in these models is not different from more sophisticated models of dark energy. We study a transient regime where the parameter λ has to be less than √ 3 and the fixed point ΩQ = 1 has not been reached. All values o...
متن کاملBenzofurazane as a new redox label for electrochemical detection of DNA: towards multipotential redox coding of DNA bases.
Benzofurazane has been attached to nucleosides and dNTPs, either directly or through an acetylene linker, as a new redox label for electrochemical analysis of nucleotide sequences. Primer extension incorporation of the benzofurazane-modified dNTPs by polymerases has been developed for the construction of labeled oligonucleotide probes. In combination with nitrophenyl and aminophenyl labels, we ...
متن کاملFine-tuning of a ferrocene[porphyrin]ITO redox cascade for efficient sequential electron transfer commenced by an S2 photoexcited special-pair mimic.
A systematic series of ferrocene/porphyrin redox cascade architectures was assembled through a slipped-cofacial porphyrin dimer on ITO electrode in optimizing the anodic photocurrent generation to perform the highest quantum yield compared to reported values on ITO electrodes.
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ژورنال
عنوان ژورنال: New J. Chem.
سال: 2014
ISSN: 1144-0546,1369-9261
DOI: 10.1039/c4nj01050g